At the Nail Artisan of Manatee County salon in Central Florida, five diverse, hardworking manicurists try to make ends meet in a staid economy while managing perilous personal lives awash in drama. Amidst all the silk wraps, pedicures and polish treatments, salon owner Desna, who lives with and cares for her mentally ill twin brother, leads a staff that includes best friend Jennifer, now sober and raising two kids from a previous relationship; enigmatic Ann, who provides security for the salon; mild-mannered preppy and ex-convict Polly; and Virginia, who becomes easily bored and impatient with her job. Also hanging around the salon are shady redneck Roller; ambulance coach Bryce, Jennifer's husband who is also newly sober; and Uncle Daddy, a dangerous, deeply Catholic and actively bisexual crime boss.
Desna is an attractive woman who lives with her brother and owns a nail salon with her 3 best friends. She and her crew are involved with the local drug gang by trafficking through the shop; Desi is also seeing Roller who is one of the drug king pin's main dealers. Things get complicated when a new associate is introduced and Roller doesn't follow through on his deal with paying Desna for her help with the drug organization.